HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naproxen → Desmethylnaproxen
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naproxen | HCID 156391 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | Desmethylnaproxen | HCID 162920 | — |
Reaction Steps
A mixture of Naproxen (500 g, 2.774 mmol) and 48% HBr (1500 ml) was refluxed for 10 hours, poured onto ice water (3000 ml) and stirred for 30 minutes. Crude 5 was filtered, dried (380 grams, 81%) and used as such for next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691364B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-f871a269090541699e7a8a7929ea70d4 |
| Source note | uspto-grants-2010_04 |