反应详情

To a mixture of 6-(4-nitrophenoxy)hexanoic acid 53 (50 g, 197.62 mmol) and ethylene glycol(200 ml) was passed dry HCl gas for one hr. During HCl gas bubbling the temp. rose to 60° C. The crude reaction mass was poured onto ice (1 Kg), extracted into ethyl acetate, washed with water (2×250 ml), dried over sodium sulphate and distilled to get crude 54, which was purified by column chromatography on silica gel using benzene as eluant to get pure 54 (46 g, 78.3%) as a light yellow syrup.

1. customfor one hr
2. customDuring HCl gas bubbling the temp
3. customrose to 60° C
4. customThe crude reaction mass
5. additionwas poured onto ice (1 Kg)
6. extractionextracted into ethyl acetate
7. washwashed with water (2×250 ml)
8. dry with materialdried over sodium sulphate
9. distillationdistilled
10. customto get crude 54, which
11. customwas purified by column chromatography on silica gel