Ammonium Chloride → HCID 68576919, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of LDA (prepared from BuLi, 1.6 M in hexane, 75 ml, 0.12 mol and diisopropylamine, 12.2 g, 0.12 mol) in THF (50 ml) was added 2-methyl-cyclohex-2-enone (11.0 g, 0.1 mol) at −78° C. The mixture was stirred for 1 h at −78° C. and prenyl bromide 17.88 g, 0.12 mol) was added. The mixture was stirred over night, while the temperature was allowed to rise to room temperature. MTBE (50 ml) and sat. NH4Cl were added, the organic phase was separated and washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was distilled in a Kugelrohr oven to yield 9.8 g (55%) of a slightly yellow oil.

Provenance & Evidence