2-(Tributylstannyl)pyrazine → (11beta,16alpha,17beta)-17-Cyclopropylcarbonyl-16-methyl-11-[4-(pyrazin-2-yl)phenyl]estra-4,9-dien-3-one

Participants

Reaction Conditions

Reaction Steps

According to the procedure described in example 8, (11β,16α,17β)-11-(4-bromophenyl)-17-cyclopropylcarbonyl-16-methylestra-4,9-dien-3-one and 2-tributylstannylpyrazine were heated in a microwave at 135° C. (150 W, 25 minutes) to give the title compound (35% yield). 1H NMR (400 MHz, CDCl3): δ 0.33 (s, 3H), 0.84-2.86 (m, 24H), 4.47 (d, J=7 Hz, 1H), 5.81 (s, 1H), 7.30-7.34 (m, 2H), 7.92-7.96 (m, 2H), 8.49 (d, J=3 Hz, 1H), 8.61 (dd, J=3 and 1 Hz, 1H), 9.01 (d, J=1 Hz, 1H).

Provenance & Evidence