Triethylamine → HCID 70896830, compound

Participants

Reaction Conditions

Reaction Steps

Triethylamine (2.9 mL, 20.7 mmol) and methanesulfonyl chloride (0.8 mL, 10.3 mmol) are added in the stated order to a solution of the allylic alcohol obtained in example (4) 1.b) (2.6 g, 6.9 mmol) in 1,2 dichloroethane (50 mL), cooled to 0° C. The reaction is monitored by thin layer chromatography (diethyl ether). The mixture is stirred at 0° C. until mesylate formation is complete, then maintained at room temperature until the product has completely formed. The solution is diluted with dichloromethane (50 mL) and washed with cold water, a 10% aqueous solution of cold hydrochloric acid, a saturated NaHCO3 solution, a saturated NaCl solution then dried over anhydrous Na2SO4. The solvent is removed under reduced pressure and the product purified by flash chromatography on a silica gel column using diethyl ether as eluant. 1.54 g (74%) of a white solid are obtained.

Provenance & Evidence