HCID 11817172, compound → HCID 11287703, compound

HRID 638841Notes

Reaction equation

HRID 638841 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]2[N:7]3[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:8]3[S:9][C:5]=2[CH:4]=1>C(Cl)Cl.CN(C=O)C.O=[Mn]=O>[CH:13]([C:11]1[N:10]=[C:8]2[N:7]([CH:12]=1)[C:6]1[CH:15]=[CH:16][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[S:9]2)=[O:14]

Participants

4

Reactant 1

HCID 11817172HCID 11817172, compound

Product 1

HCID 11287703HCID 11287703, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideSolventHCID 22350042dichloromethane N,N-dimethylformamideSolvent

Procedure

2-Formyl-7-methoxyimidazo[2,1-b]-benzthiazole was prepared according to the procedure outlined in Example 1, (Step 3). Starting from 7-methoxy imidazo[2,1-b]-benzthiazole-2-methanol (4.0 g 17 mmol) in methylene chloride/DMF (300 mL: 50 mL) and active MnO2 (12 g, excess), 822 mg (21% Yield) of the aldehyde derivative was isolated as brown solid. (M+H) 233.

Workup

  1. customwas isolated as brown solid

Sources & evidence

ORD record
ord-344c0598bd6249278dd471d2e52046c5
Source dataset
uspto-grants-2010_04
Patent number
US07691842B2

Reaction notes

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