Ethyl bromopyruvate → HCID 396585, compound

HRID 638870Notes

Reaction equation

[F:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.Br[CH2:13][C:14](=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[F:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]3[CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 66144Ethyl bromopyruvate

HCID 3199542-Amino-6-fluorobenzothiazole

Product 1

HCID 396585HCID 396585, compoundYield 19.1%

Procedure

Ethyl 7-fluoro-imidazo[2,1-b]-benzthiazole-2-carboxylate was prepared according to the procedure as outlined in Example 1, (Step 1). Starting from 6-fluoro-2-amino benzothiazole (10.0 g, 59.5 m.mol) and ethyl bromopyruvate (17.4 g, 89.2 mmol), 3.0 g (19% Yield) of ethyl 7-fluoro-imidazo[2,1-b]-benzthiazole-2-carboxylate was isolated as a brown semi-solid. (M+H) 265.

Workup

customEthyl 7-fluoro-imidazo[2,1-b]-benzthiazole-2-carboxylate was prepared

Sources & evidence

ORD record: ord-861ffe00516b4ee0b37faa2cbf125f24
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07691842B2

Reaction notes

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