Trifluoroacetic acid → HCID 118863116, compound

Participants

Reaction Steps

To a solution of 6-(3-chlorophenoxy)-5-((4-chlorophenyl)(hydroxy)methyl)-1-methyl-3-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (45 mg, 0.076 mmol) in TFA (0.9 mL) was added Et3SiH (0.3 mL). The reaction was stirred at RT for 15 min then diluted with EA (20 mL) and water (20 mL). The organic layer was dried over Na2SO4 and concentrated to give 3-(5-(4-chlorobenzyl)-6-(3-chlorophenoxy)-1-methyl-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)propyl 2,2,2-trifluoroacetate (40 mg, 89.5% yield) as an oil. LCMS: MH+ 587 and TR=2.308 min.

Provenance & Evidence