Hydrochloric Acid → 4-Methoxy-3-propyl-5-(trifluoromethoxy)aniline--hydrogen chloride (1/1)

Participants

Reaction Steps

To a stirred solution of 1-allyl-2-methoxy-5-nitro-3-trifluoromethoxybenzene (1.9 g, 6.86 mmol, 1 eq.) in MeOH (26 mL) at room temperature was added aqueous HCl solution (3.4 mL, 3.0 M) followed by 10% Pd/C (256 mg). The reaction mixture was stirred under H2 atmosphere for 17 h, filtered through a pad of celite and concentrated in vacuo to give 4-methoxy-3-propyl-5-trifluoromethoxyphenylamine hydrochloride (1.6 g). The product was used without further purification.

Provenance & Evidence