Methyl iodide → 4-Bromo-2-(trifluoromethoxy)thioanisole

HRID 638947Notes

Reaction equation

HRID 638947 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[C:4]([O:9][C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH3:14]I>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH3:14])=[C:4]([O:9][C:10]([F:11])([F:13])[F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 27364254-Bromo-2-(trifluoromethoxy)thiophenol

Product 1

HCID 187114734-Bromo-2-(trifluoromethoxy)thioanisoleYield 85%

Procedure

4-Bromo-1-methylthio-2-trifluoromethoxybenzene was prepared from 4-bromo-2-trifluoromethoxybenzenethiol and methyl iodide by following Method C. The reaction was conducted at room temperature overnight. The crude residue was chromatographed in 20% EtOAc/Hexanes to afford 4-bromo-1-methylthio-2-trifluoromethoxybenzene (85% yield).

Workup

  1. customThe crude residue was chromatographed in 20% EtOAc/Hexanes

Sources & evidence

ORD record
ord-fc978bf4db084307963b86bd10333ec6
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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