HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 5,6-Dimethoxybiphenyl-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 3-Iodo-4,5-dimethoxybenzoic acid | HCID 230459 | — |
| Product | 5,6-Dimethoxybiphenyl-3-carboxylic acid | HCID 68685209 | 88% |
Reaction Steps
5,6-Dimethoxybiphenyl-3-carboxylic acid was prepared by coupling phenylboronic acid with 3-iodo-4,5-dimethoxybenzoic acid according to Method P. The crude product was purified via flash column chromatography on silica gel (5% MeOH in CH2Cl2 as an eluent) to give the desired acid in 88% yield. ESMS: m/z 257.3 [M−H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691843B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-2695f8d50e7f419586a0f61c2dc40278 |
| Source note | uspto-grants-2010_04 |