Trifluoroacetic acid → HCID 68687078, compound

Participants

Reaction Steps

To a solution of (+)-trans-1-(3,4-dimethoxy-5-propylbenzoyl)-3-ethylazetidine-2-carboxylic acid tert-butyl ester (160 mg, 0.41 mmol, 1 eq.) in dry DCM (3.5 mL) at room temperature was added TFA (1.5 mL). The resulting reaction mixture stirred at room temperature for 2 h. The solvent was removed in vacuo and dried under high vacuum. The residue was dissolved in ether and washed with 2% NaOH solution. The aqueous layer was acidified with 1 M HCl and extracted with EtOAc. The organic layer dried over Na2SO4, filtered, and concentrated in vacuo to afford (+)-trans-1-(3,4-dimethoxy-5-propylbenzoyl)-3-ethylazetidine-2-carboxylic acid in 80% yield, which was used without further purification. ESMS: m/z 336.3 [M+H].

Provenance & Evidence