HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-nitroanisole → 2-Fluoro-4-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-nitroanisole | HCID 565654 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Fluoro-4-methoxyaniline | HCID 3756383 | 98.5% |
Reaction Steps
A solution of 3-fluoro-4-nitrophenyl methyl ether (28.1 g, 164 mmol) in ethanol (200 mL) was hydrogenated with palladium on charcoal. The reaction mixture was filtered through Kieselguhr and evaporated under vacuum to afford the product as an oil (22.8 g, 98%); MS (+ve ion electrospray) m/z 141 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691850B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-7c75fe74df6a4fff82dd53bdd71fe028 |
| Source note | uspto-grants-2010_04 |