Nitrilooxonium tetrafluoroborate → HCID 87503465, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-bromo-8-fluoro-6-(methoxy)-3-quinolinamine (3 g, 11.1 mmol) in anhydrous THF (40 mL) cooled down to −9° C., with an ethanol/ice bath, was treated with nitrosonium tetrafluoroborate (1.4 g, 12.2 mmol) added portionwise over 20 minutes. The reaction mixture was stirred for 30 minutes at −2° C. under argon atmosphere. A precipitate was formed which was filtered, washed with cold THF and dried in vacuo overnight to afford the product as a yellow solid (3.2 g, 79%). MS (+ve ion electrospray) m/z 370 (MH+).

Provenance & Evidence