HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (R)-2-(6-Methoxy-[1,5]-naphthyridin-4-yl)oxirane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (R)-2-Bromo-1-(6-methoxy-[1,5]-naphthyridin-4-yl)ethanol | HCID 23400264 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-2-(6-Methoxy-[1,5]-naphthyridin-4-yl)oxirane | HCID 23400263 | 92% |
Reaction Steps
(R)-2-Bromo-1-(6-methoxy-[1,5]-naphthyridin-4-yl)ethanol (4.8 g, 0.017 mol) in methanol (20 ml) was stirred with potassium carbonate (2.6 g, 0.019 mol) for 1 hour, then evaporated and chromatographed on silica gel (ethyl acetate-hexane-dichloromethane) to give a solid (3.14 g, 92%), (91% ee by chiral HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691850B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-72ac8f1277f14964a647c8fdfdcd71f0 |
| Source note | uspto-grants-2010_04 |