Phosphorus tribromide → 4-Bromo-6-methoxyquinoline

HRID 639005ノート

反応式

HRID 639005 の反応式
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:15]>CN(C=O)C>[Br:15][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 178487890HCID 178487890、化合物

生成物 1

HCID 111607474-Bromo-6-methoxyquinoline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 4-hydroxy-6-methoxyquinoline (1.20 g, 70.5 mmole) in DMF (60 mL) at RT was added PBr3 (8.0 mL, 84.6 mmole) dropwise. After 2 h, the reaction contents were poured onto H2O (300 mL) and the product filtered and washed with H2O to give, after drying under high vacuum, the title compound (14.3 g, 87%) as a light yellow solid: LC-MS (ES) m/e 233 (M+H)+.

後処理

  1. customthe reaction contents
  2. additionwere poured onto H2O (300 mL)
  3. filtrationthe product filtered
  4. washwashed with H2O
  5. customto give
  6. customafter drying under high vacuum

出典と根拠

ORDレコード
ord-b49356b8d075479c963e95e5a4aa352b
出典データセット
uspto-grants-2010_04
特許番号
US07691850B2

反応ノート

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