反应详情

To a stirred solution of 4-hydroxy-6-methoxyquinoline (1.20 g, 70.5 mmole) in DMF (60 mL) at RT was added PBr3 (8.0 mL, 84.6 mmole) dropwise. After 2 h, the reaction contents were poured onto H2O (300 mL) and the product filtered and washed with H2O to give, after drying under high vacuum, the title compound (14.3 g, 87%) as a light yellow solid: LC-MS (ES) m/e 233 (M+H)+.

1. customthe reaction contents
2. additionwere poured onto H2O (300 mL)
3. filtrationthe product filtered
4. washwashed with H2O
5. customto give
6. customafter drying under high vacuum