反应详情

A solution of Methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate (788 mg) in dioxan (120 ml)/water (30 mL) was treated dropwise over 2 hours with 0.5M NaOH solution (8 mL) and stirred overnight. After evaporation to approx. 3 ml, water (5 mL) was added and 2M HCl to pH4. The precipitated solid was filtered off, washed with a small volume of water and dried under vacuum to give a solid (636 mg); MS (APCl−) m/z 209 ([M−H]−, 5%), 165([M-COOH]−, 100%).

1. customAfter evaporation to approx. 3 ml, water (5 mL)
2. additionwas added
3. filtrationThe precipitated solid was filtered off
4. washwashed with a small volume of water
5. customdried under vacuum