反应详情

A mixture of methyl 6-amino-5-bromopyridine-2-carboxylate (19.8 g) (T. R. Kelly and F. Lang, J. Org. Chem. 61, 1996, 4623-4633) and 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (34.3 g) in acetonitrile (340 mL) under argon was heated to 40° C. for 1 hour, 60° C. for 1 hour and then 80° C. overnight. After partitioning between EtOAc and water (500 mL each) the aqueous fraction was re-extracted with EtOAc (300 mL) and the combined organic solution dried with MgSO4 and evaporated. Chromatography (20% then 30% EtOAc in hexane) separated various byproducts from the required ester (2.09 g); MS (+ve ion electrospray) m/z 249 and 251 (MH+, 100%)

1. custom80° C. overnight
2. customAfter partitioning between EtOAc and water (500 mL each) the aqueous fraction
3. extractionwas re-extracted with EtOAc (300 mL)
4. dry with materialthe combined organic solution dried with MgSO4
5. customevaporated
6. customChromatography (20% then 30% EtOAc in hexane) separated various byproducts from the required ester (2.09 g)