Methane, dichloromethoxy- → 7-Fluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde

HRID 639061Notes

Reaction equation

HRID 639061 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][CH2:8][O:9][C:4]=2[CH:3]=1.[CH3:12][O:13]C(Cl)Cl>[Ti](Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:11]([CH:12]=[O:13])=[CH:10][C:5]2[O:6][CH2:7][CH2:8][O:9][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 21004Methane, dichloromethoxy-HCID 124645456-Fluoro-2,3-dihydro-1,4-benzodioxine

Product 1

HCID 146448837-Fluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde

Reagents, catalysts & solvents 1

HCID 24193Titanium TetrachlorideCatalyst

Procedure

7-Fluoro-2,3-dihydrobenzo[1,4]dioxine-6-carboxaldehyde was prepared from 6-fluoro-2,3-dihydrobenzo[1,4]dioxine [V. Daukas et al Chemija, 1999, 10 (1), 59] by reaction of dichloromethyl methyl ether and titanium tetrachloride: LC-MS (ES) m/e 155 (M+H)+.

Sources & evidence

ORD record
ord-2a77af026d174780ae5e0cde1ae4581a
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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