Trifluoroacetic acid → HCID 59254366, compound

Participants

Reaction Steps

To a stirred solution of 1,1-dimethylethyl(3S)-3{[(trifluoroacetyl)amino]methyl}-1-pyrrolidinecarboxylate (2.96 g, 10.0 mmole), in CH2Cl2 (50 mL) at RT was added TFA (25 mL). After 2 h, the reaction contents were concentrated under vacuum. The remaining residue was dissolved in (CHCl3/i-PrOH, 10:1) and washed with saturated aqueous NaHCO3. The organic phase was separated and dried over Na2SO4. Concentration under vacuum afforded the title compound (1.86 g, 95%) as a yellow oil: LC-MS (ES) m/e 197 (M+H)+.

Provenance & Evidence