反应详情

To a solution of phenylmethyl[(3S)-3-pyrrolidinylmethyl]carbamate (127 mg, 0.54 mmole) in DMF (1 mL) was added 8-ethenyl-7-fluoro-2-(methyloxy)-1,5-naphthyridine (0.10 g, 0.49 mmole). After 24 h at 100° C., the reaction contents were purified on silica gel (CHCl3/MeOH, 9:1, containing 5% NH4OH) to afford the title compound (0.16 g, 77%) as a light yellow oil: LC-MS (ES) m/e 439 (M+H)+.

1. customthe reaction contents
2. customwere purified on silica gel (CHCl3/MeOH, 9:1, containing 5% NH4OH)