Potassium Cyanide → HCID 59026120, compound

Participants

Reaction Steps

To a stirred solution of phenylmethyl 3-oxo-1-pyrrolidinecarboxylate (1.0 g, 4.56 mmole) and KCN (0.81 g, 12.54 mmole) in THF (5 mL) and H2O (15 mL) at 0° C. was added NaHSO3 (1.14 g, 10.9 mmole) in H2O (5.0 mL). After 3 h, the reaction contents were concentrated in vacuo, extracted with CHCl3 (2×100 mL), and the organics dried over Na2SO4. Purification on silica (hexanes/EtOAc, 1:1) afforded the title compound (0.92 g, 82%) as a light yellow oil: LC-MS (ES) m/e 247 (M+H)+.

Provenance & Evidence