1,4-Dioxane hydrochloride → HCID 178479734, compound

HRID 639124Notes

Reaction equation

HRID 639124 reaction equation
[OH:1]/[N:2]=[C:3]1\[CH2:4][N:5](C(OC(C)(C)C)=O)[CH2:6][C@H:7]\1[CH2:8][NH:9][C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11].[ClH:27].O1CCOCC1>C(Cl)Cl>[ClH:27].[OH:1]/[N:2]=[C:3]1/[C@H:7]([CH2:8][NH:9][C:10](=[O:11])[O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:6][NH:5][CH2:4]/1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 87503005tert-butyl (3Z,4R)-3-hydroxyimino-4-(phenylmethoxycarbonylaminomethyl)pyrrolidine-1-carboxylate

Product 1

HCID 178479734HCID 178479734, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve 1,1-dimethylethyl(3Z,4R)-3-(hydroxyimino)-4-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-1-pyrrolidinecarboxylate (0.90 g, 2.53 mmol) in methylene chloride (10 mL). Add HCl/dioxane (excess) and stir at ambient temperature for 3 hours. Concentrate solution under reduced pressure. (0.66 g, quant). LCMS: m/z 254.4 (MH+).

Sources & evidence

ORD record
ord-ddab4d2a1d7f4a43a9a1ab6efd97aa65
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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