Hydrochloric Acid → HCID 86616821, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl((3S,4R)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)carbamate (327 mg, 0.843 mmol) in MeOH (4 mL) at 25° C. was added dropwise a 4M HCl in dioxane solution (1.5 mL, 5.9 mmol). After 12 h, the solution was concentrated and the residue neutralized with excess MP carbonate resin in DCM to afford the title compound (242 mg, quant.) as a yellow oil: LCMS (ES) m/e 289 (M+H).

Provenance & Evidence