Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl cyanoacetate → HCID 21110161, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4-Cyanobenzaldehyde | HCID 66042 | — |
| 반응물 | 3-{[3-(Trifluoromethyl)phenyl]amino}but-2-enenitrile | HCID 5075287 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 21110161 | HCID 21110161 | — |
반응 단계
Under argon, 100 mg (0.44 mmol) of the compound of Example 2A, 57.97 mg (0.44 mmol) 4-formylbenzonitrile and 50.01 mg (0.44 mmol) ethyl cyanoacetate are dissolved in 2 ml ethanol. 3.76 mg (4.4 μl, 0.04 mmol) piperidine are added, and the mixture is stirred at reflux overnight. After cooling down to room temperature, the formed crystals are filtered and washed twice with ethanol. The crude product is purified by column chromatography with cyclohexane/ethyl acetate mixtures as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691854B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-0364a46c3a01475783ca2d9054f91de2 |
| 출처 메모 | uspto-grants-2010_04 |