Malononitrile → 2-Amino-4-(4-cyanophenyl)-6-methyl-1-[3-(trifluoromethyl)phenyl]-1,4-dihydro-3,5-pyridinedicarbonitrile

関与物質

反応手順

Under argon, 750 mg (3.32 mmol) of the compound of Example 2A, 434.79 mg (3.32 mmol) 4-formylbenzonitrile and 219.04 mg (3.32 mmol) malononitrile are dissolved in 5 ml ethanol. 28.23 mg (33 μl, 0.33 mmol) piperidine are added, and the mixture is stirred at reflux overnight. The product is crystallised from the reaction mixture at 0° C. The formed crystals are filtered, washed twice with cold ethanol and dried.

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