HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbenzylamine → 10-[(2,2'-Dimethyl-1,1'-biphenyl-4-YL)carbonyl]-N-(2-methylbenzyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbenzylamine | HCID 6993 | — |
| Reactant | 2,2,2-Trichloro-1-{10-[(2,2'-dimethyl-1,1'-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone | HCID 16038471 | — |
| Product | 10-[(2,2'-Dimethyl-1,1'-biphenyl-4-YL)carbonyl]-N-(2-methylbenzyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide | HCID 16038609 | — |
Reaction Steps
The title compound was synthesized in the manner of Example 13 from 2,2,2-trichloro-1-{10-[(2,2′-dimethyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 6 and 2-methylbenzylamine, m.p. 128-130° C. MS [(+)ESI, m/z]: 538 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691848B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b9a3855694a444fa950d2afc9a142c3b |
| Source note | uspto-grants-2010_04 |