2-(4-Chlorophenyl)ethylamine → HCID 68680577, compound

HRID 639224Notes

Reaction equation

HRID 639224 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([CH3:34])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[Cl:37][C:38]1[CH:46]=[CH:45][C:41]([CH2:42][CH2:43][NH2:44])=[CH:40][CH:39]=1>>[Cl:37][C:38]1[CH:46]=[CH:45][C:41]([CH2:42][CH2:43][NH:44][C:3]([C:5]2[N:14]3[C:8]([CH2:9][N:10]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=5[CH3:33])=[C:23]([CH3:34])[CH:22]=4)=[O:20])[C:11]4[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=4[CH2:13]3)=[CH:7][CH:6]=2)=[O:4])=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 160384712,2,2-Trichloro-1-{10-[(2,2'-dimethyl-1,1'-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

Product 1

HCID 68680577HCID 68680577, compound

Procedure

The title compound was synthesized in the manner of Example 13 from 2,2,2-trichloro-1-{10-[(2,2′-dimethyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 6 and 4-chlorophenethylamine, m.p. 169-171° C. MS [(+)ESI, m/z]: 574 [M+H]+ Anal. Calcd for C36H32CIN3O2: C, 75.31; H, 5.62; N, 7.32. Found: C, 75.32; H, 5.48; N, 7.23.

Sources & evidence

ORD record
ord-e72e4d86c5ae45ceb55e224d2464c8cc
Source dataset
uspto-grants-2010_04
Patent number
US07691848B2

Reaction notes

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