反应详情

温度

0 °C

To a solution of 4-bromo-3-hydroxybenzoic acid (30 mmol) in methanol (100 mL) was added concentrated sulfuric acid (2.6 mL). The solution was heated at reflux for 5 hours, cooled to 0° C., and then brought to pH 7 by adding saturated aqueous sodium carbonate. The solution was evaporated to one-third the original volume. Water was added and the product was extracted into ethyl acetate. The organic extracts were washed with water and brine and dried over anhydrous sodium sulfate. Evaporation gave 6.15 g (89%) of the product as a white solid, m.p. 130-132° C.

1. temperatureThe solution was heated
2. temperatureat reflux for 5 hours
3. customThe solution was evaporated to one-third the original volume
4. additionWater was added
5. extractionthe product was extracted into ethyl acetate
6. washThe organic extracts were washed with water and brine
7. dry with materialdried over anhydrous sodium sulfate
8. customEvaporation