Benzenebutanamine → 10-[(2-Methoxy-2'-methyl-1,1'-biphenyl-4-YL)carbonyl]-N-(4-phenylbutyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide

Participants

Reaction Steps

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and 4-phenylbutylamine. Purification was performed using HPLC with a normal phase column. Elution with a mixture of etoxynonafluorobutane and methanol gave the title compound (61% yield) as a yellow powder, m.p. 154-159° C. MS [(+)ESI, m/z]: 584 [M+H]+

Provenance & Evidence