Phenylethanolamine → HCID 16039137, compound

Participants

Reaction Steps

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and (±)-2-amino-1-phenylethanol. Purification was performed using HPLC with a normal phase column. Elution with a two phase solvent system (A=hexane, B=dichloromethane/methanol, 4:1) gave the title compound in 77% yield, m.p. 214-215° C. MS [(+)ESI, m/z]: 572 [M+H]+

Provenance & Evidence