p-Chlorophenoxyacetyl chloride → 10-[(4-Chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

HRID 639269Notes

Reaction equation

HRID 639269 reaction equation
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[NH:7][CH2:6][C:5]=12.[Cl:15][C:16]1[CH:26]=[CH:25][C:19]([O:20][CH2:21][C:22](Cl)=[O:23])=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:26]=[CH:25][C:19]([O:20][CH2:21][C:22]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][N:4]3[CH:3]=[CH:2][CH:1]=[C:5]3[CH2:6]2)=[O:23])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

Product 1

HCID 6868042910-[(4-Chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Procedure

This compound was prepared from 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine and 4-chlorophenoxyacetyl chloride in the manner of Example 75, step B, m.p. 120-122° C. MS [(+)ESI, m/z]: 353 [M+H]+ Anal. Calcd for C20H17CIN2O2:C, 68.09; H, 4.86; N, 7.94. Found: C, 67.82; H, 4.87; N, 7.87.

Sources & evidence

ORD record
ord-9a0db9f8e9a741f59b03a0125f0ef711
Source dataset
uspto-grants-2010_04
Patent number
US07691848B2

Reaction notes

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