Benzo-1,3-dioxole-5-methylamine → N-(1,3-Benzodioxol-5-ylmethyl)-10-[(4-chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide

Participants

Reaction Steps

The title compound was synthesized from 2,2,2-trichloro-1-{10-[(4-chlorophenoxy) acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 67 (0.3 mmol) and piperonylamine (2.2 eq.) in the manner of Example 68, m.p. 168-169° C. MS [(+)ESI, m/z]: 530 [M+H]+ Anal. Calcd for C29H24CIN3O5: C, 65.72; H, 4.56; N, 7.93. Found: C, 65.79; H, 4.59; N, 7.89.

Provenance & Evidence