Triethylamine → Methyl 4-{[({10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2, 1-C][1,4]benzodiazepin-3-YL}carbonyl)amino]methyl}benzoate

関与物質

反応手順

The title compound was synthesized from 2,2,2-trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 75 (0.3 mmol), methyl 4-(aminomethyl)benzoate hydrochloride (2.2 eq.) and triethylamine (2.4 eq.) in the manner of Example 68, m.p.165-167° C. MS [(+)ESI, m/z]: 558 [M+H]+ Anal. Calcd for C31H28CIN3O5: C, 66.72; H, 5.06; N, 7.53. Found: C, 66.46; H, 5.26; N, 7.24.

情報源と証拠