Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)benzylamine → 10-{[(4-Bromophenyl)thio]acetyl}-N-[3-(trifluoromethyl)benzyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| 반응물 | 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone | HCID 16039367 | — |
| 생성물 | 10-{[(4-Bromophenyl)thio]acetyl}-N-[3-(trifluoromethyl)benzyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide | HCID 16039441 | — |
반응 단계
The title compound was synthesized in the manner of Example 81 from 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone of Example 80 and 3-trifluoromethylbenzylamine, m.p. 102° C. MS [(+)ESI, m/z]: 614 [M+H]+ Anal. Calcd for C29H23BrF3N3O2S: C, 56.69; H, 3.77; N, 6.84. Found: C, 56.79; H, 3.66; N, 6.76.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691848B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-09f7d86c378f40a6a7fe49f89cbf18ad |
| 출처 메모 | uspto-grants-2010_04 |