Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2,3,4-Tetrahydro-1-naphthylamine → 10-{[(4-Bromophenyl)thio]acetyl}-N-(1,2,3,4-tetrahydronaphthalen-1-YL)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2,3,4-Tetrahydro-1-naphthylamine | HCID 18066 | — |
| 반응물 | 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone | HCID 16039367 | — |
| 생성물 | 10-{[(4-Bromophenyl)thio]acetyl}-N-(1,2,3,4-tetrahydronaphthalen-1-YL)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide | HCID 16039443 | — |
반응 단계
The title compound was synthesized in the manner of Example 81 from 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone of Example 80 and 1,2,3,4-tetrahydronaphthalen-1-ylamine, m.p. 163-165° C. MS [(+)ESI, m/z]: 586 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691848B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-a17256946c4641f2b3e6ab3f333d6214 |
| 출처 메모 | uspto-grants-2010_04 |