HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 6-(4-Fluoro-benzyloxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Fluorobenzylic alcohol | HCID 68022 | — |
| Reactant | Methyl 6-bromo-5-chloro-2-pyrazinecarboxylate | HCID 59254839 | — |
| Reactant | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68567445 | — |
| Product | 6-(4-Fluoro-benzyloxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68565288 | 13% |
Reaction Steps
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (example 10, step c), the title compound was synthesized from 6-bromo-5-chloro-pyrazine-2-carboxylic acid methyl ester, (4-fluoro-phenyl)-methanol (commercially available), pyrrolidine (commercially available) and subsequent saponification with KOH in 13% yield. m/z (ES+): 318.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691863B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-e72cafc6a78b4db198fe2c92a692d0cf |
| Source note | uspto-grants-2010_04 |