HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 5-Pyrrolidin-1-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Methyl 6-bromo-5-chloro-2-pyrazinecarboxylate | HCID 59254839 | — |
| Reactant | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68567445 | — |
| Product | 5-Pyrrolidin-1-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid | HCID 68569431 | 41% |
Reaction Steps
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (example 10, step c), the title compound was synthesized from 6-bromo-5-chloro-pyrazine-2-carboxylic acid methyl ester, 2,2,2-trifluoro-ethanol (commercially available), pyrrolidine (commercially available) and subsequent saponification with KOH in 41% yield. m/z (ES+): 292.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691863B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-4941a6651ad5431b952f51154e56dd8a |
| Source note | uspto-grants-2010_04 |