HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+)-L-Leucine methyl ester → (S)-2-{[6-(2-Methoxy-ethoxy)-5-piperidin-1-yl-pyrazine-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| Reactant | 6-(2-Methoxy-ethoxy)-5-piperidin-1-yl-pyrazine-2-carboxylic acid | HCID 68569013 | — |
| Product | (S)-2-{[6-(2-Methoxy-ethoxy)-5-piperidin-1-yl-pyrazine-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester | HCID 24831736 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-(2-methoxy-ethoxy)-5-piperidin-1-yl-pyrazine-2-carboxylic acid and (S)-leucine methyl ester (commercially available). m/z (ES+): 409.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691863B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-eded60bcc6d944c086454b9fc90e59ab |
| Source note | uspto-grants-2010_04 |