HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Leucinol → 6-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Leucinol | HCID 111307 | — |
| Reactant | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| Reactant | 6-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic-acid | HCID 68569317 | — |
| Product | 6-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831739 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-(2,2-dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic-acid and (S)-leucinol (commercially available). m/z (ES+): 395.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691863B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-a0478db692fa437faab347935684e59c |
| Source note | uspto-grants-2010_04 |