Methyl 2-amino-2-ethylbutanoate → HCID 24831905, compound

HRID 639336Notes

Reaction equation

HRID 639336 reaction equation
OC[C@@H](NC(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)CC(C)C.[CH2:26]([N:28]([CH2:42][CH3:43])[C:29]1[N:30]=[CH:31][C:32]([C:39]([OH:41])=O)=[N:33][C:34]=1[O:35][CH:36]([CH3:38])[CH3:37])[CH3:27].[CH3:44][O:45][C:46](=[O:53])[C:47]([NH2:52])([CH2:50][CH3:51])[CH2:48][CH3:49]>>[CH3:44][O:45][C:46](=[O:53])[C:47]([NH:52][C:39]([C:32]1[CH:31]=[N:30][C:29]([N:28]([CH2:26][CH3:27])[CH2:42][CH3:43])=[C:34]([O:35][CH:36]([CH3:37])[CH3:38])[N:33]=1)=[O:41])([CH2:50][CH3:51])[CH2:48][CH3:49]

Participants

4

Reactant 3

HCID 13412527Methyl 2-amino-2-ethylbutanoateHCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amideHCID 68568948HCID 68568948, compound

Product 1

HCID 24831905HCID 24831905, compound

Procedure

In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 5-diethylamino-6-isopropoxy-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 381.2 (M+H).

Sources & evidence

ORD record
ord-4cebba760156435c93a32d77e7728255
Source dataset
uspto-grants-2010_04
Patent number
US07691863B2

Reaction notes

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