化工社化工社化学信息打印报告 · 仅供科研参考
L-亮氨醇 → 6-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | L-亮氨醇 | HCID 111307 | — |
| 反应物 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 反应物 | 6-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid | HCID 68566571 | — |
| 产物 | 6-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24829469 | — |
反应步骤
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid and (S)-leucinol (commercially available). m/z (ES+): 441.3 (M+H).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07691863B2 |
| 来源数据集 | uspto-grants-2010_04 |
| ORD ID | ord-1ae79a1b2cdb4870be3430c008591723 |
| 来源说明 | uspto-grants-2010_04 |