HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 2-(5-Methoxy-2-nitrophenyl)-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | 5-Methoxy-2-nitrobenzaldehyde | HCID 230371 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(5-Methoxy-2-nitrophenyl)-1,3-dioxolane | HCID 57249027 | 85% |
Reaction Steps
The mixture 5-methoxy-2-nitrobenzaldehyde (1 eq), ethylene glycol (1.4eq) and p-toluene sulfonic acid monohydrate (catalytic amount) in toluene was heated to reflux with a Dean-Stark apparatus for 16 hours. The mixture was then concentrated and passed through a plug of silica to give 2-(1,3-dioxolan-2-yl)-4-methoxy-1-nitrobenzene in 85-90% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691866B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-0ef20e714ea348988ef2c59f5bbbf2b4 |
| Source note | uspto-grants-2010_04 |