反应详情

6-methoxyquinazolin-2-ol (1eq) and phosphorus oxychloride (2-10eq) was refluxed for 2 hours. The reaction mixture was concentrated and neutralized with sodium carbonate, which was then filtered off. The concentrate was partitioned between ethyl acetate and water. The organic layer was then washed with brine dried and concentrated. The crude was subjected to column chromatography (10% Acetone in hexane) to afford 2-chloro-6-methoxyquinazoline as a beige color solid in 90% yield.

1. concentrationThe reaction mixture was concentrated
2. filtrationwas then filtered off
3. customThe concentrate was partitioned between ethyl acetate and water
4. washThe organic layer was then washed with brine
5. customdried
6. concentrationconcentrated