反应详情

10 g (42 mMol) of Diethyl-[2-(4-nitro-phenoxy)-ethyl]-amine is dissolved in 100 mL of ethanol and subjected to catalytic hydration at rt using 894 mg of Pd/C. After filtration trough HYFLO and removal of the solvent under reduced pressure, the crude product is purified by bulb-to-bulb distillation (140° C.) to obtain 4-(2-diethylamino-ethoxy)-phenylamine. Title compound: ES-MS: 209 [M+H]+; single peak at tR=2.3 min (System 2).

1. customsubjected to catalytic hydration at rt
2. filtrationAfter filtration trough HYFLO and removal of the solvent under reduced pressure
3. distillationthe crude product is purified by bulb-to-bulb distillation (140° C.)