N-Boc-4-hydroxyaniline → HCID 68570539, compound

HRID 639383Notes

Reaction equation

HRID 639383 reaction equation
ClC1C=CC(C2C(C3C=CN=C(N[C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH2:27][CH:28]5[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]5)[CH:21]=4)N=3)=CNN=2)=CC=1.[CH3:35][C:36]([O:39][C:40]([NH:42]C1C=CC(O)=CC=1)=[O:41])([CH3:38])[CH3:37]>>[C:36]([O:39][C:40](=[O:41])[NH:42][C:25]1[CH:20]=[CH:21][C:22]([O:26][CH2:27][CH:28]2[CH2:29][CH2:30][N:31]([CH3:34])[CH2:32][CH2:33]2)=[CH:23][CH:24]=1)([CH3:38])([CH3:37])[CH3:35]

Participants

3

Reactant 2

HCID 2756771N-Boc-4-hydroxyanilineHCID 178480345HCID 178480345, compound

Product 1

HCID 68570539HCID 68570539, compound

Procedure

[4-(1-Methyl-piperidin-4-ylmethoxy)-phenyl]-carbamic acid tert-butyl ester is prepared as described for [3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-carbamic acid tert-butyl ester (see Example 27) using 4-N-BOC-Aminophenol (AstaTech; B56686). Title compound: ES-MS: 321.1 [M+H]+; single peak at tR=4.55 min (System 1).

Sources & evidence

ORD record
ord-b60b63bbae2f4c86bbd60b8efc562922
Source dataset
uspto-grants-2010_04
Patent number
US07691855B2

Reaction notes

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