3-Bromoaniline → 3-(4-Methylpiperazin-1-yl)aniline

HRID 639384Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11](N)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.BrC1C=C([NH2:22])C=CC=1>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([NH2:22])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 115623-Bromoaniline

HCID 7372534-(4-Methylpiperazin-1-yl)aniline

Product 1

HCID 115646133-(4-Methylpiperazin-1-yl)aniline

Procedure

3-(4-Methyl-piperazin-1-yl)-phenylamine is prepared as described for 4-(4-methyl-piperazin-1-yl)-phenylamine (see Example 1) using 3-bromo-phenylamine.

Sources & evidence

ORD record: ord-63c7a49b4b874ef290f073aceed9018c
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07691855B2

Reaction notes

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