3,4,5-Trimethoxyaniline → HCID 178493066, compound

HRID 639387Notes

Reaction equation

HRID 639387 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:13]([C:14]2[CH:19]=[CH:18][N:17]=[C:16](S(C)(=O)=O)[N:15]=2)=[CH:12][NH:11][N:10]=1.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34])[NH2:29]>CC(O)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:13]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:29][C:28]3[CH:30]=[C:31]([O:35][CH3:36])[C:32]([O:33][CH3:34])=[C:26]([O:25][CH3:24])[CH:27]=3)[N:15]=2)=[CH:12][NH:11][N:10]=1

Participants

4

Reactant 2

HCID 322853,4,5-TrimethoxyanilineHCID 178504844HCID 178504844, compound

Product 1

HCID 178493066HCID 178493066, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

{4-[3-(2,4-Dichloro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}-(3,4,5-trimethoxy-phenyl)-amine is synthesized from 4-[3-(2,4-dichloro-phenyl)-1H-pyrazol-4-yl]-2-methanesulfonyl-pyrimidine in analogy to a literature procedure (Klutchko et al., Journal of Medicinal Chemistry, 1998, Vol. 41, No. 17, 3276-3292) using 3,4,5-trimethoxyaniline (Fluka 92129) and glacial HOAc.

Sources & evidence

ORD record
ord-b7ac6d948c9c40ed98c30d778c576ba3
Source dataset
uspto-grants-2010_04
Patent number
US07691855B2

Reaction notes

Loading…