Methanol → HCID 10027267, compound

HRID 639410Notes

Reaction equation

HRID 639410 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([N:26]5[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]5)=[CH:22][CH:21]=4)[N:14]=3)=[CH:11][NH:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:33]O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]4[CH:21]=[CH:22][C:23]([N:26]5[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]5)=[CH:24][CH:25]=4)[N:14]=3)=[CH:11][N:10]([CH3:33])[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 178480709HCID 178480709, compound

Product 1

HCID 10027267HCID 10027267, compound

Procedure

The title compound is prepared as described in Example 55 starting from {4-[3-(4-chloro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine (Example 1) and using methanol instead.

Sources & evidence

ORD record
ord-2af2e4cbf5c74c028a72f84999c8cdc9
Source dataset
uspto-grants-2010_04
Patent number
US07691855B2

Reaction notes

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