Dichloromethane → HCID 23154177, compound

Participants

Reaction Steps

Metachloroperbenzoic acid (1.25 g) was added, under cooling with ice, to a methylene chloride solution (10 mL) containing ethyl 4-tert-butylsulfinylaminocyclohexane-carboxylate (1.0 g) as prepared by the above-described preparation method, and stirring was effected at room temperature for 3 hrs. The reaction mixture, after being diluted with ethyl acetate, was washed with an aqueous saturated sodium-hydrogencarbonate and sodium-chloride solutions successively, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resultant residue was separated and purified by silica-gel chromatography (C-300, hexane:ethyl acetate=1:1) to give ethyl 4-tert-butylsulfonylamino-cyclohexanecarboxylate composed mainly of the trans isomer (673 mg).

Provenance & Evidence